Organelle inheritance

Across TCGA patient cohorts, RNA activity of the Organelle inheritance pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLU, ABCA5, and KLF15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organelle inheritance activity versus CLU in PDAC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CLU →	-1.091	-0.217	<.001	<.001	3	4
PDAC	ABCA5 →	-0.280	-0.103	.004	.007	3	4
PDAC	KLF15 →	-0.735	-0.174	.009	<.001	3	4
OV	FAM107A →	-1.630	-0.150	.001	.001	3	4
UCEC	DTYMK →	+0.990	+0.120	<.001	<.001	3	4
OV	USP44 →	-0.657	-0.135	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048308 vs CLU — PDAC

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