Organelle inheritance

Across TCGA cell cohorts, RNA activity of the Organelle inheritance pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUGCT, DRG1, and ANXA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SUGCT grouped by Organelle inheritance-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SUGCT →	-1.744	-0.803	.002	.002	3	4
BLOOD_Lymphoma	DRG1 →	+0.737	+0.550	<.001	<.001	3	4
BLOOD_Leukemia	ANXA3 →	+2.651	+0.230	.001	.005	2	5
URINARY_TRACT	C8orf76 →	+0.804	+0.378	.001	.004	3	4
BONE	CCDC112 →	+0.659	+0.357	<.001	<.001	3	4
OESOPHAGUS	ZFAND1 →	+1.838	+0.237	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SUGCT by Organelle inheritance activity — KIDNEY

Explore this box plot interactively →