Organelle inheritance

Across TCGA cell cohorts, RNA activity of the Organelle inheritance pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDK1, SULT1A3, and MAD2L1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organelle inheritance activity versus CDK1 in BLOOD_Leukemia (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CDK1 →	+0.672	+0.122	.006	.003	3	6
LUNG_SCLC	SULT1A3 →	+0.938	+0.139	.001	.006	3	5
LIVER	MAD2L1 →	+0.945	+0.394	.005	.005	3	5
LARGE_INTESTINE	KIF22 →	+0.620	+0.160	.003	<.001	3	5
LIVER	GAK →	+0.808	+0.273	.007	.003	3	5
LUNG_NSCLC_LUAD	NELFA →	+0.472	+0.111	.004	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048308 vs CDK1 — BLOOD_Leukemia

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