Positive regulation of isotype switching to IgG isotypes

Across TCGA patient cohorts, RNA activity of the Positive regulation of isotype switching to IgG isotypes pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STX11, SNRPD3, and AQP9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of isotype switching to IgG isotypes activity versus STX11 in CCRCC (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	STX11 →	+0.534	+0.224	.001	.002	3	4
CCRCC	SNRPD3 →	-0.305	-0.181	.002	.002	3	4
CCRCC	AQP9 →	+1.427	+0.270	<.001	<.001	3	4
LSCC	CSF3R →	+0.824	+0.316	<.001	.008	3	4
CCRCC	CHRM3 →	-0.894	-0.215	<.001	<.001	3	4
OV	PGBD1 →	-0.583	-0.147	.007	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048304 vs STX11 — CCRCC

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