Positive regulation of isotype switching to IgG isotypes

Across TCGA cell cohorts, RNA activity of the Positive regulation of isotype switching to IgG isotypes pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP17, RTCB, and LSR, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of isotype switching to IgG isotypes activity versus MMP17 in LUNG_NSCLC_LUAD (Pearson r = -0.95).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MMP17 →	-2.603	-1.485	.003	<.001	3	3
LUNG_SCLC	RTCB →	-0.546	-0.329	.001	<.001	3	2
LUNG_SCLC	LSR →	+3.931	+0.326	<.001	.002	3	2
LUNG_SCLC	LZTS2 →	+1.231	+0.178	.003	.009	3	2
LUNG_SCLC	TP53I3 →	+2.876	+0.388	<.001	.001	3	2
LUNG_SCLC	DNAJC16 →	+1.019	+0.366	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048304 vs MMP17 — LUNG_NSCLC_LUAD

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