Positive regulation of isotype switching to IgA isotypes

Across TCGA patient cohorts, RNA activity of the Positive regulation of isotype switching to IgA isotypes pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUF2, NEK2, and ESPL1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of isotype switching to IgA isotypes activity versus NUF2 in BRCA (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NUF2 →	+1.132	+0.432	<.001	.003	3	8
BRCA	NEK2 →	+1.263	+0.486	<.001	<.001	3	7
UCEC	ESPL1 →	+1.172	+0.158	<.001	<.001	3	7
LUAD	SPAG5 →	+0.968	+0.223	<.001	.001	3	7
UCEC	RAD51AP1 →	+1.010	+0.157	<.001	<.001	3	7
UCEC	HMMR →	+1.002	+0.177	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048298 vs NUF2 — BRCA

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