Positive regulation of isotype switching to IgA isotypes

Across TCGA cell cohorts, RNA activity of the Positive regulation of isotype switching to IgA isotypes pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INSL6, DEPDC7, and RECK, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of isotype switching to IgA isotypes activity versus INSL6 in OESOPHAGUS (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	INSL6 →	+0.116	+1.431	<.001	<.001	3	2
OESOPHAGUS	DEPDC7 →	-2.160	-1.463	.005	.001	3	2
OESOPHAGUS	RECK →	+1.053	+1.273	<.001	<.001	3	2
BLOOD_Lymphoma	WDR93 →	-0.276	-1.230	.006	.009	3	2
LUNG_NSCLC_LUAD	PRR4 →	+1.893	+1.508	.006	.002	3	2
LUNG_NSCLC_LUAD	STX2 →	+2.115	+1.508	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048298 vs INSL6 — OESOPHAGUS

Explore this scatter interactively →