Organelle fusion

Across TCGA patient cohorts, RNA activity of the Organelle fusion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, CLPX, and JPT1_S131, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organelle fusion activity versus RPL5 in GBM (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL5 →	-0.186	-0.044	.003	<.001	3	7
LUAD	CLPX →	-0.249	-0.026	.001	<.001	3	7
LSCC	JPT1_S131 →	-0.541	-0.023	.009	.002	3	7
GBM	BYSL →	-0.252	-0.027	<.001	<.001	3	6
OV	RPL11 →	-0.318	-0.026	<.001	.003	3	6
GBM	CLP1 →	-0.280	-0.040	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048284 vs RPL5 — GBM

Explore this scatter interactively →