Vesicle docking

Across TCGA patient cohorts, RNA activity of the Vesicle docking pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTBP, DNAJC2, and KPNB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle docking activity versus MTBP in PDAC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MTBP →	-0.281	-0.149	<.001	<.001	3	6
HNSC	DNAJC2 →	-0.602	-0.128	.005	.005	3	5
UCEC	KPNB1 →	-0.309	-0.268	.001	<.001	3	5
UCEC	KIF20A →	-1.153	-0.276	.001	<.001	3	5
UCEC	BRIX1 →	-0.400	-0.336	<.001	<.001	3	5
UCEC	CENPA →	-0.872	-0.264	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048278 vs MTBP — PDAC

Explore this scatter interactively →