Clathrin coat assembly

Across TCGA patient cohorts, RNA activity of the Clathrin coat assembly pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFYVE16, RAPGEF2, and MED13L, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Clathrin coat assembly activity versus ZFYVE16 in UVM (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	ZFYVE16 →	+1.156	+0.060	<.001	<.001	3	33
DLBC	RAPGEF2 →	+1.571	+0.104	<.001	<.001	3	32
KIRP	MED13L →	+1.000	+0.070	<.001	<.001	3	32
UVM	ZFC3H1 →	+1.196	+0.071	<.001	<.001	3	32
THYM	TSSK4 →	+0.992	+0.060	<.001	<.001	3	32
UVM	RICTOR →	+1.174	+0.072	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048268 vs ZFYVE16 — UVM

Explore this scatter interactively →