Clathrin coat assembly

Across TCGA patient cohorts, RNA activity of the Clathrin coat assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYBL2, TTK, and TICRR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Clathrin coat assembly activity versus MYBL2 in BRCA (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MYBL2 →	-0.863	-0.129	.001	.001	3	6
UCEC	TTK →	-1.024	-0.189	.001	<.001	3	5
UCEC	TICRR →	-0.693	-0.149	.008	.003	3	5
BRCA	KIF15 →	-0.758	-0.194	<.001	<.001	3	5
BRCA	CBX2 →	-0.933	-0.127	.001	.001	3	5
BRCA	MCM10 →	-0.659	-0.117	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048268 vs MYBL2 — BRCA

Explore this scatter interactively →