Clathrin coat assembly

Across TCGA cell cohorts, RNA activity of the Clathrin coat assembly pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ST3GAL3, CEP170, and FBXO43, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ST3GAL3 grouped by Clathrin coat assembly-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ST3GAL3 →	-1.513	-0.289	.001	.006	3	6
LUNG_NSCLC_LUSC	CEP170 →	-1.141	-0.692	.003	.008	3	5
LUNG_NSCLC_LUSC	FBXO43 →	-1.134	-0.488	<.001	.006	3	5
LUNG_NSCLC_LUSC	INAVA →	+3.735	+0.572	<.001	<.001	3	5
LUNG_NSCLC_LUAD	AKIP1 →	-0.495	-0.370	.003	.009	3	5
URINARY_TRACT	BBS10 →	-0.986	-0.339	.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ST3GAL3 by Clathrin coat assembly activity — OESOPHAGUS

Explore this box plot interactively →