Clathrin coat assembly

Across TCGA cell cohorts, RNA activity of the Clathrin coat assembly pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPV, NPM3, and HMGB2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Clathrin coat assembly activity versus CENPV in KIDNEY (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CENPV →	-2.797	-0.280	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	NPM3 →	-1.445	-0.220	.001	.007	3	7
BLOOD_Leukemia	HMGB2 →	-0.952	-0.316	<.001	<.001	3	7
LUNG_NSCLC_LUSC	VASN →	+4.060	+0.302	.001	.004	2	8
LUNG_SCLC	SLC35C1 →	+0.754	+0.219	.003	<.001	3	7
KIDNEY	PTMA →	-1.035	-0.212	.002	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048268 vs CENPV — KIDNEY

Explore this scatter interactively →