Clathrin coat assembly

Across TCGA cell cohorts, RNA activity of the Clathrin coat assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AP2S1, AP2B1, and AP2M1, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Clathrin coat assembly activity versus AP2S1 in LIVER (Pearson r = 0.71).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	AP2S1 →	+1.304	+0.298	.007	.006	3	19
LUNG_NSCLC_LUSC	AP2B1 →	+1.048	+0.411	.001	<.001	3	15
STOMACH	AP2M1 →	+0.997	+0.211	.002	.008	3	14
LUNG_NSCLC_LUSC	PICALM →	+1.037	+0.353	.001	.001	3	14
LARGE_INTESTINE	AP2A1 →	+0.942	+0.334	<.001	<.001	3	13
STOMACH	RPN2 →	+1.125	+0.245	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048268 vs AP2S1 — LIVER

Explore this scatter interactively →