Behavioral response to pain

Across TCGA patient cohorts, RNA activity of the Behavioral response to pain pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LCK, RIN2_S486, and DHRS3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Behavioral response to pain activity versus LCK in UCEC (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LCK →	-0.541	-0.105	<.001	.004	3	6
GBM	RIN2_S486 →	+0.484	+0.058	<.001	<.001	3	6
GBM	DHRS3 →	+0.665	+0.089	<.001	<.001	3	5
OV	HEATR5A →	+0.223	+0.045	.003	<.001	3	5
OV	LUZP1_S745 →	+0.834	+0.062	<.001	<.001	3	5
BRCA	PPCS →	+0.273	+0.040	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048266 vs LCK — UCEC

Explore this scatter interactively →