Behavioral response to pain

Across TCGA cell cohorts, RNA activity of the Behavioral response to pain pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARSB, SERPINB8, and ABLIM3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Behavioral response to pain activity versus ARSB in LUNG_NSCLC_LUSC (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ARSB →	+1.266	+2.081	.008	<.001	2	6
BREAST	SERPINB8 →	+1.322	+1.159	.001	<.001	3	5
SKIN	ABLIM3 →	+2.615	+1.382	.008	.007	3	5
CNS	ACOT8 →	+0.490	+0.337	.003	<.001	3	4
BLOOD_Leukemia	ZNF326 →	-0.698	-1.075	.002	.005	3	4
OVARY	CCDC85B →	+1.548	+1.196	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048266 vs ARSB — LUNG_NSCLC_LUSC

Explore this scatter interactively →