Behavioral response to pain

Across TCGA cell cohorts, RNA activity of the Behavioral response to pain pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THBS1, CAPN2, and FLNA, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Behavioral response to pain activity versus THBS1 in LUNG_SCLC (Pearson r = 0.79).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	THBS1 →	+2.831	+1.555	<.001	<.001	3	18
BREAST	CAPN2 →	+2.279	+1.427	<.001	<.001	3	13
LUNG_NSCLC_LUAD	FLNA →	+1.247	+0.620	.003	.009	3	10
LUNG_NSCLC_LUSC	ACTN1 →	+1.764	+1.929	.004	<.001	3	9
LARGE_INTESTINE	PDLIM7 →	+1.763	+1.177	.004	.002	3	9
LUNG_NSCLC_LUSC	MYH9 →	+2.002	+1.718	.004	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048266 vs THBS1 — LUNG_SCLC

Explore this scatter interactively →