Response to pain

Across TCGA patient cohorts, RNA activity of the Response to pain pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RGS2, SELPLG, and SRGN, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to pain activity versus RGS2 in OV (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RGS2 →	+1.130	+0.121	.001	.002	3	3
PDAC	SELPLG →	+0.438	+0.136	.002	<.001	3	3
OV	SRGN →	+0.608	+0.096	.006	.002	3	3
PDAC	CD53 →	+0.483	+0.109	.002	.003	3	3
CCRCC	ZNF852 →	-0.242	-0.134	.005	.001	3	3
CCRCC	HTR7P1 →	-0.235	-0.097	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048265 vs RGS2 — OV

Explore this scatter interactively →