Response to pain

Across TCGA cell cohorts, RNA activity of the Response to pain pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OCRL, EPHA2, and RNF19B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OCRL grouped by Response to pain-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OCRL →	-0.318	-0.658	.004	.003	3	4
BREAST	EPHA2 →	-1.712	-0.492	.002	.008	3	4
LUNG_NSCLC_LUAD	RNF19B →	-0.652	-0.504	<.001	<.001	3	4
BLOOD_Lymphoma	AHCTF1 →	-1.453	-0.446	.003	.007	2	4
BREAST	FSD1 →	-1.757	-0.451	<.001	.002	3	3
BREAST	TPD52L1 →	+1.263	+0.335	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OCRL by Response to pain activity — CNS

Explore this box plot interactively →