Response to pain

Across TCGA cell cohorts, RNA activity of the Response to pain pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THBS1, ZBTB46, and SMAD9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to pain activity versus THBS1 in SKIN (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	THBS1 →	+4.130	+1.111	.002	.003	2	6
BREAST	ZBTB46 →	-0.899	-1.034	.001	.002	3	5
STOMACH	SMAD9 →	-1.884	-1.290	.001	.005	3	4
STOMACH	HFM1 →	-1.044	-1.394	.001	.004	3	4
STOMACH	SALL2 →	-3.718	-1.274	<.001	.005	3	4
STOMACH	RASL10B →	-2.966	-1.315	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048265 vs THBS1 — SKIN

Explore this scatter interactively →