Determination of dorsal/ventral asymmetry

Across TCGA patient cohorts, RNA activity of the Determination of dorsal/ventral asymmetry pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARPC4, TLN1_S1201, and FAP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Determination of dorsal/ventral asymmetry activity versus ARPC4 in GBM (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARPC4 →	+0.357	+0.143	<.001	<.001	3	7
GBM	TLN1_S1201 →	+0.793	+0.075	.009	.008	3	7
GBM	FAP →	+0.916	+0.150	<.001	<.001	3	7
GBM	FNDC3B →	+0.452	+0.107	<.001	<.001	3	7
LSCC	NNMT →	+0.598	+0.075	<.001	<.001	3	7
BRCA	P4HA2 →	+0.680	+0.088	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048262 vs ARPC4 — GBM

Explore this scatter interactively →