Determination of dorsal/ventral asymmetry

Across TCGA patient cohorts, RNA activity of the Determination of dorsal/ventral asymmetry pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMOD1, FERMT2, and CNRIP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Determination of dorsal/ventral asymmetry activity versus LMOD1 in COAD (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LMOD1 →	+0.902	+0.192	.007	.001	3	6
BRCA	FERMT2 →	+0.728	+0.163	.001	.002	3	6
BRCA	CNRIP1 →	+0.559	+0.147	.004	.008	3	5
LSCC	TAGLN →	+1.055	+0.276	<.001	<.001	3	5
BRCA	MSRB3 →	+0.721	+0.193	.006	<.001	3	5
LUAD	CCDC80 →	+0.640	+0.143	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048262 vs LMOD1 — COAD

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