Determination of dorsal/ventral asymmetry

Across TCGA cell cohorts, RNA activity of the Determination of dorsal/ventral asymmetry pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM122A, NDFIP2, and FAM172A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM122A grouped by Determination of dorsal/ventral asymmetry-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FAM122A →	-0.656	-0.358	.003	.005	3	3
SKIN	NDFIP2 →	+0.671	+0.639	<.001	.007	3	2
SKIN	FAM172A →	+1.175	+1.102	.002	.008	3	2
SKIN	CEP170 →	+0.811	+0.643	.001	.007	3	2
LUNG_NSCLC_LUAD	IGFBP3 →	+3.860	+0.789	<.001	.003	3	2
SKIN	ZNF18 →	+0.904	+0.951	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM122A by Determination of dorsal/ventral asymmetry activity — STOMACH

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