Negative regulation of receptor-mediated endocytosis

Across TCGA patient cohorts, RNA activity of the Negative regulation of receptor-mediated endocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPP1_S234, EPS8L2_S570, and KCNAB2_S9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of receptor-mediated endocytosis activity versus SPP1_S234 in LUAD (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SPP1_S234 →	+1.118	+0.038	.002	.003	3	5
UCEC	EPS8L2_S570 →	-0.431	-0.037	.002	.003	3	5
UCEC	KCNAB2_S9 →	+0.392	+0.046	<.001	<.001	3	5
GBM	CLSTN1 →	+0.450	+0.047	<.001	<.001	3	5
PDAC	ENO2 →	+0.385	+0.033	.005	<.001	3	5
COAD	THBS1 →	+0.728	+0.032	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048261 vs SPP1_S234 — LUAD

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