Negative regulation of receptor-mediated endocytosis

Across TCGA cell cohorts, RNA activity of the Negative regulation of receptor-mediated endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOBP, TBC1D13, and CMPK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SOBP grouped by Negative regulation of receptor-mediated endocytosis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SOBP →	-1.277	-1.065	.001	.004	3	5
LUNG_NSCLC_LUAD	TBC1D13 →	+0.634	+0.699	<.001	<.001	3	4
LUNG_SCLC	CMPK2 →	+1.597	+0.945	.002	.009	3	4
KIDNEY	FAM216A →	-0.828	-1.360	.009	.002	3	4
BREAST	FAM71E1 →	+1.220	+0.879	.003	.001	3	4
OVARY	APPL1 →	-0.901	-0.900	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SOBP by Negative regulation of receptor-mediated endocytosis activity — CNS

Explore this box plot interactively →