Negative regulation of receptor-mediated endocytosis

Across TCGA cell cohorts, RNA activity of the Negative regulation of receptor-mediated endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA2, CAVIN3, and GBP3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of receptor-mediated endocytosis activity versus ANXA2 in STOMACH (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ANXA2 →	+2.439	+0.270	.005	.003	3	9
SOFT_TISSUE	CAVIN3 →	+4.569	+0.277	.001	.001	3	8
LIVER	GBP3 →	+3.464	+0.366	.002	.001	3	8
BLOOD_Lymphoma	AHNAK →	+3.669	+0.887	<.001	.003	3	8
STOMACH	PLAUR →	+2.444	+0.316	.006	<.001	3	7
BREAST	RSAD1 →	-1.088	-0.263	.008	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048261 vs ANXA2 — STOMACH

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