Positive regulation of receptor-mediated endocytosis

Across TCGA patient cohorts, RNA activity of the Positive regulation of receptor-mediated endocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORBS1, ANKRD44, and SEPTIN4_S432, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of receptor-mediated endocytosis activity versus SORBS1 in COAD (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SORBS1 →	+0.780	+0.039	<.001	<.001	3	10
OV	ANKRD44 →	+0.460	+0.032	.003	<.001	3	10
GBM	SEPTIN4_S432 →	+0.763	+0.045	.002	.001	3	9
OV	DOCK11 →	+0.535	+0.032	.006	.007	3	9
COAD	AKAP12 →	+0.934	+0.055	<.001	<.001	3	9
HNSC	STAB1 →	+0.397	+0.065	<.001	.004	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048260 vs SORBS1 — COAD

Explore this scatter interactively →