Positive regulation of receptor-mediated endocytosis

Across TCGA patient cohorts, RNA activity of the Positive regulation of receptor-mediated endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE1A, CNRIP1, and PDE1B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of receptor-mediated endocytosis activity versus PDE1A in LSCC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PDE1A →	+0.787	+0.987	<.001	<.001	3	8
BRCA	CNRIP1 →	+0.710	+0.193	.001	.001	3	7
GBM	PDE1B →	+0.504	+0.112	<.001	<.001	3	7
UCEC	MEF2C →	+0.596	+0.171	.001	.007	3	7
BRCA	ARHGEF39 →	-0.551	-0.179	<.001	<.001	3	7
LSCC	IGFBP7 →	+0.934	+0.796	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048260 vs PDE1A — LSCC

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