Positive regulation of receptor-mediated endocytosis

Across TCGA cell cohorts, RNA activity of the Positive regulation of receptor-mediated endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STARD8, GPX8, and SUCLG2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STARD8 grouped by Positive regulation of receptor-mediated endocytosis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	STARD8 →	-1.133	-0.262	.001	.003	3	5
SKIN	GPX8 →	-0.844	-0.894	.002	.004	3	5
LUNG_SCLC	SUCLG2 →	-1.522	-0.259	<.001	.006	3	4
LUNG_SCLC	TIGD3 →	+1.228	+0.260	<.001	<.001	3	4
LUNG_SCLC	CBX2 →	+2.266	+0.291	.002	.001	3	4
LUNG_SCLC	ZNF713 →	+1.142	+0.294	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STARD8 by Positive regulation of receptor-mediated endocytosis activity — LUNG_SCLC

Explore this box plot interactively →