Positive regulation of receptor-mediated endocytosis

Across TCGA cell cohorts, RNA activity of the Positive regulation of receptor-mediated endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MARS2, HSPD1, and SLC43A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of receptor-mediated endocytosis activity versus MARS2 in LIVER (Pearson r = -0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MARS2 →	-1.007	-0.315	<.001	<.001	3	5
BREAST	HSPD1 →	-0.842	-0.267	<.001	<.001	3	5
STOMACH	SLC43A1 →	-3.212	-0.219	<.001	<.001	3	5
CNS	FAM136A →	-0.435	-0.203	.009	.007	2	6
OESOPHAGUS	TIMM50 →	-0.622	-0.237	.005	.006	3	4
LIVER	HCFC1R1 →	+1.340	+0.296	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048260 vs MARS2 — LIVER

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