Regulation of receptor-mediated endocytosis

Across TCGA patient cohorts, RNA activity of the Regulation of receptor-mediated endocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GNB4, TLN1, and CLPX, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of receptor-mediated endocytosis activity versus GNB4 in COAD (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GNB4 →	+0.357	+0.030	<.001	<.001	3	9
COAD	TLN1 →	+0.293	+0.028	.004	<.001	3	8
LUAD	CLPX →	-0.286	-0.041	<.001	<.001	3	8
CCRCC	NFATC2 →	+0.312	+0.034	.001	.002	3	8
GBM	SEPTIN4_S325 →	+0.670	+0.030	<.001	<.001	3	7
OV	RIPOR1 →	+0.306	+0.026	.003	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048259 vs GNB4 — COAD

Explore this scatter interactively →