snoRNA localization

Across TCGA patient cohorts, RNA activity of the snoRNA localization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COIL, CCDC43, and EFTUD2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snoRNA localization activity versus COIL in LSCC (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	COIL →	+0.409	+0.051	<.001	<.001	3	7
LSCC	CCDC43 →	+0.289	+0.056	<.001	<.001	3	6
LSCC	EFTUD2 →	+0.266	+0.072	<.001	<.001	3	6
LSCC	LIG3 →	+0.583	+0.079	<.001	<.001	3	6
LSCC	RECQL5 →	+0.254	+0.041	<.001	<.001	3	5
LSCC	SAP30BP_S113 →	+0.308	+0.045	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048254 vs COIL — LSCC

Explore this scatter interactively →