snoRNA localization

Across TCGA patient cohorts, RNA activity of the snoRNA localization pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBL, NCAPG, and CENPF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snoRNA localization activity versus FBL in LSCC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FBL →	+0.655	+0.248	.005	<.001	3	5
UCEC	NCAPG →	+0.716	+0.173	<.001	<.001	3	5
UCEC	CENPF →	+1.471	+0.236	<.001	<.001	3	5
HNSC	POLR1B →	+0.456	+0.198	.009	.001	3	5
UCEC	DSCC1 →	+0.645	+0.196	<.001	<.001	3	5
HNSC	SPC25 →	+0.728	+0.250	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048254 vs FBL — LSCC

Explore this scatter interactively →