Elastic fiber assembly

Across TCGA patient cohorts, RNA activity of the Elastic fiber assembly pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C7, MYH11, and ABCA9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Elastic fiber assembly activity versus C7 in OV (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C7 →	+2.130	+0.437	<.001	<.001	3	7
CCRCC	MYH11 →	+1.923	+0.918	<.001	<.001	3	7
CCRCC	ABCA9 →	+0.812	+0.884	<.001	<.001	3	7
CCRCC	LAMA2 →	+1.333	+1.187	<.001	<.001	3	7
OV	ACTA2-AS1 →	+1.134	+0.387	.001	.001	3	7
BRCA	PDE5A →	+0.758	+0.293	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048251 vs C7 — OV

Explore this scatter interactively →