Elastic fiber assembly

Across TCGA cell cohorts, RNA activity of the Elastic fiber assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF572, TESK1, and GPR176, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF572 grouped by Elastic fiber assembly-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZNF572 →	+0.272	+0.267	.001	<.001	3	4
SOFT_TISSUE	TESK1 →	-0.138	-0.224	.002	<.001	3	3
KIDNEY	GPR176 →	-0.174	-0.328	.001	.003	2	4
BONE	RTCA →	+0.337	+0.239	.002	.009	3	3
CNS	ANXA9 →	-0.335	-0.271	.001	.001	3	3
BONE	CAMK2D →	+0.239	+0.197	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF572 by Elastic fiber assembly activity — CNS

Explore this box plot interactively →