Elastic fiber assembly

Across TCGA cell cohorts, RNA activity of the Elastic fiber assembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSNAX, MRPS9, and NPIPB11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Elastic fiber assembly activity versus TSNAX in BREAST (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TSNAX →	-0.655	-1.312	.004	.002	2	4
SKIN	MRPS9 →	-0.494	-1.240	.006	<.001	3	3
SKIN	NPIPB11 →	-0.553	-1.784	<.001	<.001	3	3
OVARY	CLCN2 →	-1.311	-1.423	.003	.003	3	3
OVARY	TANC1 →	-0.954	-1.981	.005	<.001	3	3
OVARY	OBSCN →	-3.226	-2.212	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048251 vs TSNAX — BREAST

Explore this scatter interactively →