Lymphocyte chemotaxis

Across TCGA patient cohorts, RNA activity of the Lymphocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM97, RRAS, and ITGA3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphocyte chemotaxis activity versus TMEM97 in PDAC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TMEM97 →	-0.745	-0.286	<.001	.006	3	6
GBM	RRAS →	+0.588	+0.556	<.001	<.001	3	6
HNSC	ITGA3 →	+0.829	+0.226	.002	.008	3	6
GBM	FCGR3A →	+1.010	+0.550	<.001	<.001	3	5
PDAC	CAP1 →	+0.293	+0.243	.001	.002	3	5
GBM	EMP3 →	+0.669	+0.499	.002	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048247 vs TMEM97 — PDAC

Explore this scatter interactively →