Lymphocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Lymphocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC12A2, BOC, and MRPL11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphocyte chemotaxis activity versus SLC12A2 in BREAST (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SLC12A2 →	+1.807	+0.249	.001	.001	3	5
BREAST	BOC →	-2.280	-0.276	.007	.004	3	4
BREAST	MRPL11 →	-0.746	-0.251	.003	.008	3	4
SOFT_TISSUE	PHLDA2 →	+4.611	+0.212	<.001	.001	3	4
SOFT_TISSUE	PCNX2 →	+2.040	+0.212	.001	.001	3	4
SOFT_TISSUE	PLEC →	+1.574	+0.212	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048247 vs SLC12A2 — BREAST

Explore this scatter interactively →