Macrophage chemotaxis

Across TCGA patient cohorts, RNA activity of the Macrophage chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GYPC, HCLS1, and C3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macrophage chemotaxis activity versus GYPC in OV (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GYPC →	+0.761	+0.209	.005	.001	3	7
GBM	HCLS1 →	+0.889	+0.254	.001	<.001	3	7
COAD	C3 →	+1.433	+0.176	<.001	<.001	3	7
LSCC	CCDC69 →	+0.607	+0.165	<.001	<.001	3	7
LSCC	MIR223HG →	+0.802	+0.209	<.001	<.001	3	6
OV	S1PR4 →	+0.846	+0.266	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048246 vs GYPC — OV

Explore this scatter interactively →