Macrophage chemotaxis

Across TCGA cell cohorts, RNA activity of the Macrophage chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are G3BP2, DPY19L1, and R3HCC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, G3BP2 grouped by Macrophage chemotaxis-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	G3BP2 →	-0.839	-1.564	.007	.001	3	4
PANCREAS	DPY19L1 →	-1.508	-1.208	.001	.002	3	4
URINARY_TRACT	R3HCC1 →	+1.048	+1.546	.001	<.001	3	4
URINARY_TRACT	ATP6V1B2 →	+0.920	+1.403	.007	.002	3	4
BLOOD_Myeloma	PCGF6 →	-1.192	-1.489	.006	.004	3	3
BLOOD_Myeloma	TTC16 →	-0.042	-1.928	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

G3BP2 by Macrophage chemotaxis activity — BLOOD_Myeloma

Explore this box plot interactively →