Macrophage chemotaxis

Across TCGA cell cohorts, RNA activity of the Macrophage chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM106C, TBKBP1, and TUBA1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macrophage chemotaxis activity versus TMEM106C in LARGE_INTESTINE (Pearson r = 0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMEM106C →	+1.629	+0.298	.007	.009	3	3
BLOOD_Leukemia	TBKBP1 →	-1.213	-0.263	.001	.008	3	3
SKIN	TUBA1B →	+0.935	+0.348	.001	<.001	3	3
SKIN	NDUFB10 →	+1.047	+0.378	.002	<.001	3	3
BLOOD_Leukemia	MYCL →	+2.637	+0.423	.007	.007	3	2
BLOOD_Leukemia	EFNA3 →	-0.887	-0.260	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048246 vs TMEM106C — LARGE_INTESTINE

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