Epinephrine transport

Across TCGA patient cohorts, RNA activity of the Epinephrine transport pathway is significantly associated with the RNA expression of multiple genes, with the KIRP cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC29A4, ADRA2C, and LINC02600, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epinephrine transport activity versus SLC29A4 in KIRP (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	SLC29A4 →	+1.276	+0.074	<.001	<.001	3	29
SKCM	ADRA2C →	+2.056	+0.079	<.001	<.001	3	26
SARC	LINC02600 →	+1.171	+0.062	<.001	<.001	3	25
CHOL	ADRA2A →	+2.082	+0.071	.004	.008	1	26
ACC	SLC22A17 →	+1.675	+0.053	<.001	<.001	3	21
LAML	GABBR1 →	+1.663	+0.465	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048241 vs SLC29A4 — KIRP

Explore this scatter interactively →