Epinephrine transport

Across TCGA patient cohorts, RNA activity of the Epinephrine transport pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP26, GJC3, and ANKS1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epinephrine transport activity versus DUSP26 in GBM (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DUSP26 →	+1.024	+0.645	<.001	<.001	3	4
LUAD	GJC3 →	+0.559	+0.332	.006	.008	3	3
LUAD	ANKS1B →	+0.971	+0.216	.003	<.001	3	3
COAD	TPP2 →	-0.238	-0.488	.003	.001	3	3
GBM	NRXN1 →	+1.104	+0.761	.007	<.001	3	3
COAD	NUFIP1 →	-0.318	-0.493	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048241 vs DUSP26 — GBM

Explore this scatter interactively →