Sperm capacitation

Across TCGA patient cohorts, RNA activity of the Sperm capacitation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MRPS30, TSPAN6, and TTC39A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sperm capacitation activity versus MRPS30 in COAD (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MRPS30 →	+0.292	+0.082	.001	.001	3	6
UCEC	TSPAN6 →	+0.641	+0.060	<.001	.001	3	5
COAD	TTC39A →	+0.466	+0.065	<.001	<.001	3	5
COAD	MFN1 →	+0.214	+0.082	<.001	.001	3	5
COAD	MRPL43 →	+0.270	+0.085	<.001	.001	3	5
PDAC	MRPS5 →	+0.257	+0.108	.008	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048240 vs MRPS30 — COAD

Explore this scatter interactively →