Sperm capacitation

Across TCGA patient cohorts, RNA activity of the Sperm capacitation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SALL4, YKT6, and MICU1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sperm capacitation activity versus SALL4 in PDAC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SALL4 →	-0.571	-0.714	<.001	.001	3	3
PDAC	YKT6 →	-0.231	-0.596	<.001	.001	3	3
BRCA	MICU1 →	-0.310	-0.377	.001	.009	3	3
PDAC	NUP153 →	-0.311	-0.819	<.001	.001	3	3
BRCA	MIS18BP1 →	-0.469	-0.540	.002	.001	3	3
PDAC	OSER1 →	-0.315	-0.821	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048240 vs SALL4 — PDAC

Explore this scatter interactively →