Plasma membrane to endosome transport

Across TCGA patient cohorts, RNA activity of the Plasma membrane to endosome transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAP1GAP, ZNF471, and B3GAT1-DT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Plasma membrane to endosome transport activity versus RAP1GAP in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RAP1GAP →	+0.664	+0.232	.002	<.001	3	5
HNSC	ZNF471 →	+0.442	+0.274	.003	.001	3	4
COAD	B3GAT1-DT →	+0.792	+0.609	.001	.001	3	4
UCEC	ARHGAP12 →	+0.724	+0.499	<.001	<.001	3	4
OV	CENPW →	-1.181	-0.151	.001	.002	3	4
UCEC	NCMAP →	+1.690	+0.449	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048227 vs RAP1GAP — BRCA

Explore this scatter interactively →