Plasma membrane to endosome transport

Across TCGA cell cohorts, RNA activity of the Plasma membrane to endosome transport pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC11A, MCM3, and MKI67, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEC11A grouped by Plasma membrane to endosome transport-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SEC11A →	+0.637	+1.196	.003	.008	3	6
KIDNEY	MCM3 →	+0.983	+1.369	.001	<.001	3	5
KIDNEY	MKI67 →	+1.662	+1.676	.001	<.001	3	5
KIDNEY	NUP188 →	+1.185	+1.512	.001	<.001	3	5
LIVER	LARGE1 →	+2.026	+1.519	.001	.001	3	5
SKIN	PEBP1 →	+0.690	+1.009	.005	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEC11A by Plasma membrane to endosome transport activity — SOFT_TISSUE

Explore this box plot interactively →