Golgi vesicle fusion to target membrane

pathway activity — cross-omics
GO:0048210Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Golgi vesicle fusion to target membrane pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPF3, BLK, and ESR2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMDPF3 →-0.725-0.186.008.00133
LUADBLK →+0.766+0.160<.001<.00133
LUADESR2 →+0.381+0.116<.001.00233
LUADMS4A1 →+0.698+0.087.005.00633
LUADIGHD2-8 →+1.035+0.105.008.00233
PDACCYTH1 →+0.269+0.200.002<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration