"Vesicle targeting, to, from or within Golgi"

Across TCGA patient cohorts, RNA activity of the "Vesicle targeting, to, from or within Golgi" pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OSCP1, C1QB, and DHRS11_S197, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Vesicle targeting, to, from or within Golgi" activity versus OSCP1 in BRCA (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OSCP1 →	+0.480	+0.026	<.001	<.001	3	5
GBM	C1QB →	+0.585	+0.046	<.001	<.001	3	5
GBM	DHRS11_S197 →	-0.365	-0.044	.003	.001	3	5
GBM	RPL11 →	-0.173	-0.029	.002	.008	3	4
LSCC	ZNF768_S125 →	+0.469	+0.036	.004	<.001	3	4
LUAD	C11orf52_S62 →	+0.939	+0.036	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048199 vs OSCP1 — BRCA

Explore this scatter interactively →