"Vesicle targeting, to, from or within Golgi"

Across TCGA patient cohorts, RNA activity of the "Vesicle targeting, to, from or within Golgi" pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXO3B, TCF7L1, and ATAD5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Vesicle targeting, to, from or within Golgi" activity versus FOXO3B in LSCC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FOXO3B →	-0.737	-0.229	<.001	<.001	3	5
BRCA	TCF7L1 →	-0.717	-0.160	.001	.001	3	5
LSCC	ATAD5 →	-0.900	-0.191	<.001	<.001	3	5
LSCC	MCM3AP-AS1 →	-0.412	-0.168	<.001	<.001	3	5
GBM	GPR179 →	-0.402	-0.159	<.001	<.001	3	5
LSCC	SKA2 →	-0.562	-0.187	.009	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0048199 vs FOXO3B — LSCC

Explore this scatter interactively →